Article
Genotype-specific precision tumor therapy using mitochondrial DNA mutation-induced drug release system.
Science advances - 29 Sept 2023
Li Yanan, Xu Ru, Wu Yonghua, Guo Jialing, Quan Fenglei, Pei Yiran, Huang Di, Zhao Xiu, Gao Hua, Liu Junjie, Zhang Zhenzhong, Shi Jinjin, Zhang Kaixiang
Abstract excerpt
Precise killing of tumor cells without affecting surrounding normal cells is a challenge. Mitochondrial DNA (mtDNA) mutations, a common genetic variant in cancer, can directly affect metabolic homeostasis, serving as an ideal regulatory switch for precise tumor therapy. Here, we designed a mutation-induced drug release system (MIDRS), using the single-nucleotide variation (SNV) recognition ability and...
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