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Article

Differences in regional developmental origins of glioblastomas revealed by integrated molecular profiling.

Journal of neuro-oncology - 19 Jan 2026

Gensler Ryan, Ahmed A Karim, Alfonzo Horowitz Melanie, Khalifeh Jawad M, Li Marvin, Sadeghipour Negar, Abdulrahim Mostafa, Glantz Mike, Aulakh Sonikpreet, Nicolaides Theodore, Lucas Calixto-Hope G, Yegnasubramanian Srinivasan, Rincon-Torroella Jordina, Bettegowda Chetan

Abstract excerpt

BACKGROUND: High-grade IDH-wildtype gliomas are aggressive tumors with marked molecular heterogeneity. This study assessed whether tumor location reflects distinct developmental origins. METHODS: We retrospectively analyzed 5,945 high-grade IDH-wildtype gliomas using de-identified mutational and transcriptomic data. Tumors were grouped as cortical (e.g., frontal, temporal) or deep/dorsal midline (e.g., brainstem,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41553435
DOI: 10.1007/s11060-025-05409-y

Genes

ATRX
EGFR
FGFR1
FOXG1
MEOX2
MOXD1
NF1
PTEN
SMOC1
SOX10
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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