Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Intermittent antibiotic exposure of Escherichia coli biofilms drives resistance in catheter-associated infection models.

NPJ biofilms and microbiomes - 17 Jan 2026

Yoshii Yutaka, Thiriet-Rupert Stanislas, Lebeaux David, Ghigo Jean-Marc, Beloin Christophe

Abstract excerpt

The use of antibiotic lock therapy (ALT) to protect catheters from infection is still being debated due to its inconsistent effectiveness and the potential risk of promoting antibiotic resistance. Using an in vitro infection model of a pediatric venous access port, we demonstrated that 10 days of continuous therapy eradicates Escherichia coli biofilms in vitro without the emergence of antibiotic resistance. By...

Topics

Join the communities discussing this publication.

Amikacin
Anti-Bacterial Agents
Biofilms
Drug Resistance, Bacterial
Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Escherichia coli Infections

Microbial Sensitivity Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 41547958
DOI: 10.1038/s41522-025-00906-4
PMCID: PMC12894844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intermittent antibiotic exposure of Escherichia coli biofilms drives resistance in catheter-associated infection models.PMID 41547958Read ↗

Intermittent treatment of Escherichia coli biofilms leads to antibiotic resistance in vitro and in a pre-clinical in vivo model of catheter-related infectionSemantic proximity Read ↗

Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistanceSemantic proximity Read ↗

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistanceSemantic proximity Read ↗

Antibiotic resistance of bacteria in biofilms.Semantic proximity Read ↗

<i>In Vitro</i> Emergence of High Persistence upon Periodic Aminoglycoside Challenge in the ESKAPE PathogensSemantic proximity Read ↗

Emergence and spread of antibiotic resistance following exposure to antibiotics.Semantic proximity Read ↗

In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic toleranceSemantic proximity Read ↗

Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments.Semantic proximity Read ↗

Antibiotics select for novel pathways of resistance in biofilmsSemantic proximity Read ↗

Abrupt changes in antibiotic resistance.Semantic proximity Read ↗

Full and Broad-Spectrum <i>In Vivo</i> Eradication of Catheter-Associated Biofilms Using Gentamicin-EDTA Antibiotic Lock TherapySemantic proximity Read ↗

The evolution of antibiotic susceptibility and resistance during the formation of Escherichia coli biofilms in the absence of antibiotics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.