Article

Intermittent treatment of Escherichia coli biofilms leads to antibiotic resistance in vitro and in a pre-clinical in vivo model of catheter-related infection

2025-09-22

Abstract excerpt

<title>Abstract</title> Antibiotic lock therapy (ALT) to protect catheters from infection remains a topic of debate due to its variable efficacy and the unassessed risks of promoting antibiotic resistance. Using <italic>in vitro</italic> approaches and an <italic>in vivo</italic> and clinically relevant rat model of pediatric venous access ports commonly used in clinical settings, we demonstrated that a...

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Literature Corpus work: b143e3ff-c4b0-5795-8927-a63d9b155b56
DOI: 10.21203/rs.3.rs-7244857/v1

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