Article
In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance.
Nature communications - 8 Mar 2019
Dengler Haunreiter Vanina, Boumasmoud Mathilde, Häffner Nicola, Wipfli Dennis, Leimer Nadja, Rachmühl Carole, Kühnert Denise, Achermann Yvonne, Zbinden Reinhard, Benussi Stefano, Vulin Clement, Zinkernagel Annelies S
Abstract excerpt
Treatment failure in biofilm-associated bacterial infections is an important healthcare issue. In vitro studies and mouse models suggest that bacteria enter a slow-growing/non-growing state that results in transient tolerance to antibiotics in the absence of a specific resistance mechanism. However, little clinical confirmation of antibiotic tolerant bacteria in patients exists. In this study we investigate a...
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