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Chemometric evaluation of key residues affecting the stability of cold shock proteins.

Biochimica et biophysica acta. Proteins and proteomics - 1 May 2026

Buckley Jack E, Zbacnik Nathaniel J, Henry Charles S, Manning Mark Cornell

Abstract excerpt

Reduced properties, also known as amino acid descriptors, quantify changes in physicochemical properties of amino acids upon mutation. Combined with PLS (partial least squares) modeling, the impact of various mutations on the conformational stability of cold shock proteins (CSPs) was examined. Consistent with the initial evaluation of these systems, electrostatic properties at a select number of central residues...

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PMID: 41547483
DOI: 10.1016/j.bbapap.2026.141126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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