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Article

pH and Charged Mutations Modulate Cold Shock Protein Folding and Stability: A Constant pH Monte Carlo Study.

Journal of chemical theory and computation - 14 Jan 2020

de Oliveira Vinícius M, Caetano Daniel L Z, da Silva Fernando B, Mouro Paulo R, de Oliveira Antonio B, de Carvalho Sidney J, Leite Vitor B P

Abstract excerpt

The folding and stability of proteins is a fundamental problem in several research fields. In the present paper, we have used different computational approaches to study the effects caused by changes in pH and for charged mutations in cold shock proteins from Bacillus subtilis (Bs-CspB). First, we have investigated the contribution of each ionizable residue for these proteins to their thermal stability using the...

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PMID: 31756296
DOI: 10.1021/acs.jctc.9b00894

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