Article
Pediatric Malignancy in the Setting of Lynch Syndrome: A Case Series and Review of the Literature.
Pediatric blood & cancer - 1 Mar 2026
Heiman Jordan, Meade Julia, Zelley Kristin, Li Marilyn M, Goodman Victoria, Brodeur Garrett M, Katona Bryson W, MacFarland Suzanne P
Abstract excerpt
Lynch Syndrome (LS) is a hereditary cancer predisposition syndrome caused by germline pathogenic/likely pathogenic variants in mismatch repair (MMR) genes. While LS is not traditionally thought to increase childhood cancer risk, some studies have shown an increased prevalence of germline MMR variants in the pediatric oncology population. Herein, we discuss 55 individuals with pediatric cancer and LS. Of these,...
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