Article
Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.
The Journal of clinical endocrinology and metabolism - 1 Feb 2013
Agrawal Nishant, Jiao Yuchen, Sausen Mark, Leary Rebecca, Bettegowda Chetan, Roberts Nicholas J, Bhan Sheetal, Ho Allen S, Khan Zubair, Bishop Justin, Westra William H, Wood Laura D, Hruban Ralph H, Tufano Ralph P, Robinson Bruce, Dralle Henning, Toledo Sergio P A, Toledo Rodrigo A, Morris Luc G T, Ghossein Ronald A, Fagin James A, Chan Timothy A, Velculescu Victor E, Vogelstein Bert, Kinzler Kenneth W, Papadopoulos Nickolas, Nelkin Barry D, Ball Douglas W
Abstract excerpt
CONTEXT: Medullary thyroid cancer (MTC) is a rare thyroid cancer that can occur sporadically or as part of a hereditary syndrome. OBJECTIVE: To explore the genetic origin of MTC, we sequenced the protein coding exons of approximately 21,000 genes in 17 sporadic MTCs. PATIENTS AND DESIGN: We sequenced the exomes of 17 sporadic MTCs and validated the frequency of all recurrently mutated genes and other genes of...
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