Article
Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network.
Molecular cell - 22 Jan 2026
Halim Stephanie, Sebastian Rebecca M, Liivak Kristi E, Patrick Jessica E, Hui Tiffani, Amici David R, Giacomelli Andrew O, Rios Paulina, Butty Vincent L, Hahn William C, Sánchez-Rivera Francisco J, Mendillo Marc L, Lin Yu-Shan, Shoulders Matthew D
Abstract excerpt
Protein mutational landscapes are shaped by how amino acid substitutions affect stability and folding or aggregation kinetics. These properties are modulated by cellular proteostasis networks. Heat shock factor 1 (HSF1) is the master regulator of cytosolic and nuclear proteostasis. Chronic HSF1 activity upregulation is a hallmark of cancer cells, potentially because upregulated proteostasis factors facilitate the...
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