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Article

RAS-variant allele frequency as a potential prognostic marker of overall survival in patients with metastatic colorectal cancer.

Cancer treatment and research communications - 1 Jan 2026

Nindra Udit, Hong Jun Hee, Hong Martin, Lim Stephanie Hui-Su, Asghari Ray, Farzin Mahtab, Rutland Tristan, Chantrill Lorraine, Brungs Daniel, Wong Mark, Nagrial Adnan, Roberts Tara, Becker Therese, Ng Weng, Chua Wei

Abstract excerpt

BACKGROUND: Presence of RAS mutations in mCRC are negatively correlated with OS. NGS enables detailed information regarding the heterogeneity of RAS mutations including specific amino acid changes as well as variant allele frequency (VAF). Recently, VAF has been postulated to have a role in identifying resistance to treatments in multiple solid tumours but its role as a prognostic marker of OS in mCRC is not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41539177
DOI: 10.1016/j.ctarc.2026.101103

Genes

PIK3CA
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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