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Article

Structure and sequence characteristics of 5'-stem-loop 1 modulate the escape from nsp1-mediated repression in SARS-CoV-2 variants.

Nucleic acids research - 23 Apr 2026

Schoth Julian B, Schwedt Inge, Philipp Susanne, Toews Sabrina, Schübel Leonie, Wacker Anna, Schwalbe Harald, Weigand Julia E

Abstract excerpt

Several SARS-CoV-2 variants have evolved with clinical relevance due to their structural and functional impact on viral proteins and genomic RNA structures. A comprehensive structural and functional characterization of single-nucleotide variations in the 5'-untranslated region (UTR) of SARS-CoV-2 has remained elusive. The co-evolution of 5'-UTR stem-loop 1 (SL1) and non-structural protein (nsp) 1 mutants are of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42049233
DOI: 10.1093/nar/gkag364
PMCID: PMC13122180

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