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Article

Genetic Profiling of Mammary Periductal Stromal Tumors With Histologic Correlation Highlights High-Grade and Low-Grade Groups and Similarities to Phyllodes Tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2026

Krings Gregor, Bean Gregory R, Hosfield Elizabeth M, Rowe J Jordi, Geradts Joseph, Chen Yunn-Yi

Abstract excerpt

Periductal stromal tumors (PDST) of the breast are rare biphasic neoplasms with morphologic similarities to phyllodes tumors (PTs). The histologic spectrum of PDST is broad but has not been well characterized, and its genetic underpinnings remain unknown. We profiled PDST by targeted next-generation sequencing in correlation with their histomorphology, immunophenotype, and clinical characteristics (n = 15). All...

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Source

Identifiers

PMID: 41534841
DOI: 10.1016/j.modpat.2026.100961

Genes

CDKN2A
TERT
TP53
ARID2
CD34
EGFR
HMGA2
KMT2B
LZTR1
MED12
NF1
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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