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Article

Functional footprints of homologous recombination deficiency in prostate cancer revealed by ctDNA fragmentation and transcription factor accessibility.

British journal of cancer - 1 Mar 2026

Vlachos Georgios, Moser Tina, Lazzeri Isaac, Moser Matthias J, Glawitch Lisa, Bauernhofer Emil Thomas, Eberhard Anna, Beichler Christine, Sadeghi Hanieh, Blatterer Jasmin, Kühberger Stefan, Monsberger Nina, Terbuch Angelika, Kashofer Karl, Geigl Jochen B, Bauernhofer Thomas, Heitzer Ellen

Abstract excerpt

BACKGROUND: Homologous recombination deficiency (HRD) is a predictive biomarker for response to PARP inhibitors and platinum-based therapies in prostate cancer (PCa). However, current diagnostic approaches, often limited to BRCA1/2 mutation testing or genomic scars, fail to capture the full spectrum of HRD. Tissue-based testing is further hampered by tumour heterogeneity and biopsy limitations in patients with...

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Identifiers

PMID: 41514011
DOI: 10.1038/s41416-025-03301-0
PMCID: PMC12960696

Genes

BRCA2
BRCA1
PTEN
RB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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