Article
BRCA2, ATM, and CDK12 Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2021
Warner Evan, Herberts Cameron, Fu Simon, Yip Steven, Wong Amanda, Wang Gang, Ritch Elie, Murtha Andrew J, Vandekerkhove Gillian, Fonseca Nicolette M, Angeles Arkhjamil, Beigi Arshia, Schönlau Elena, Beja Kevin, Annala Matti, Khalaf Daniel, Chi Kim N, Wyatt Alexander W
Abstract excerpt
PURPOSE: DNA damage repair (DDR) defects are common across cancer types and can indicate therapeutic vulnerability. Optimal exploitation of DDR defects in prostate cancer requires new diagnostic strategies and a better understanding of associated clinical genomic features. EXPERIMENTAL DESIGN: We performed targeted sequencing of 1,615 plasma cell-free DNA samples from 879 patients with metastatic prostate cancer....
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