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DNA repair defects in prostate cancer: impact for screening, prognostication and treatment

5 Oct 2018

Abstract excerpt

Failure of effective DNA damage repair is a hallmark of cancer, but was previously underappreciated as a driver of aggressive prostate cancer. However, recent international sequencing efforts have revealed that both germline and somatic alterations within the homologous recombination and mismatch repair pathways are relatively common in lethal metastatic disease. BRCA2 gene alterations are particularly prevalent...

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PMID: 30281887
DOI: 10.1111/bju.14576

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