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Genomic attributes of homology-directed DNA repair deficiency in metastatic prostate cancer

7 Dec 2021

Abstract excerpt

Cancers with homology-directed DNA repair (HRR) deficiency exhibit high response rates to poly(ADP-ribose) polymerase inhibitors (PARPi) and platinum chemotherapy. Though mutations disrupting BRCA1 and BRCA2 associate with HRR deficiency (HRRd), patterns of genomic aberrations and mutation signatures may be more sensitive and specific indicators of compromised repair. Here, we evaluated whole-exome sequences from...

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DNA Repair Mechanisms
Genetic factors in colorectal cancer
PARP inhibition in cancer therapy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34877933
DOI: 10.1172/jci.insight.152789

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