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Article

The role of gene polymorphisms in the occurrence of gastroesophageal reflux disease: A systematic review and meta-analysis of genetic association studies.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Mar 2026

Argyrou Alexandra, Papadakos Stavros P, Karniadakis Ioannis, Michailidou Elisavet, Vogli Stamatina, Vlachogiannakos Jannis

Abstract excerpt

BACKGROUND: Gastroesophageal reflux disease (GERD) is a prevalent gastrointestinal disorder with multifactorial etiology, including genetic components. Despite numerous genetic association studies (GAS), the role of specific gene polymorphisms in GERD susceptibility remains unclear due to inconsistent findings. AIMS: To systematically review GAS on GERD and conduct a meta-analysis to evaluate the association...

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Share to Gastroesophageal Reflux
Share to CYP2C19 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GNB3 gene

Share to Genetic Association Studies

Share to Genetic Predisposition to Disease

Share to Heterotrimeric GTP-Binding Proteins

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 41513492
DOI: 10.1016/j.dld.2025.12.014

Genes

GNB3
CYP2C19
IL1B
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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