Causal associations between gastroesophageal reflux disease and gastroduodenal ulcer: A two-sample mendelian randomisation study.

Abstract excerpt

INTRODUCTION: Both common diseases are gastroesophageal reflux disease (GERD) and gastroduodenal ulcer. However, whether GERD causes gastroduodenal ulcers remains uncertain or if the reverse relationship exists. Using Mendelian randomisation, we investigated the potential causal link between GERD and gastroduodenal ulcers. METHODS: We conducted genome-wide genetic analyses based on extensive datasets: the...

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• Gastroesophageal Reflux
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Peptic Ulcer
• Polymorphism, Single Nucleotide