[Pathophysiology of osteoporosis].

Abstract excerpt

Osteoporosis must be viewed as a pathological condition which affects the entire skeleton and is characterized by a low bone mass in combination with microarchitectural changes particularly of cancellous bone, both adding to the fragility of bone at distinct sites of the axial as well as the perpendicular skeleton. The two major determinants of bone mass and mineral density in later life in both sexes, i.e., (i)...

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