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Article

Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila.

PLoS genetics - 1 Apr 2017

Gamberi Chiara, Hipfner David R, Trudel Marie, Lubell William D

Abstract excerpt

Progressive cystic kidney degeneration underlies diverse renal diseases, including the most common cause of kidney failure, autosomal dominant Polycystic Kidney Disease (PKD). Genetic analyses of patients and animal models have identified several key drivers of this disease. The precise molecular and cellular changes underlying cystogenesis remain, however, elusive. Drosophila mutants lacking the translational...

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Identifiers

PMID: 28406902
DOI: 10.1371/journal.pgen.1006694
PMCID: PMC5390980

Genes

BICC1

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