Article
Transcriptome-wide association study of cardiovascular outcomes in chronic kidney disease: The chronic renal insufficiency cohort.
HGG advances - 9 Apr 2026
Lin Bridget M, Wen Jia, Horimoto Andrea R V R, Zhou Lingbo, Huang Shuai, Dobre Mirela, Go Alan S, Li Yun, Franceschini Nora
Abstract excerpt
Transcriptome-wide association studies (TWASs) are powerful for identifying gene-trait associations by integrating gene expression and genome-wide association data, but findings may be impacted by the choice of gene expression reference. We performed TWAS of cardiovascular outcomes using multi-tissue and ancestry-matched gene expression references. We used data from the Chronic Renal Insufficiency Cohort Study...
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