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Article

The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity.

PloS one - 1 Jan 2015

Kidd Ambrose R, Muñiz-Medina Vanessa, Der Channing J, Cox Adrienne D, Reiner David J

Abstract excerpt

Wnt signaling controls various aspects of developmental and cell biology, as well as contributing to certain cancers. Expression of the human Rho family small GTPase Wrch/RhoU is regulated by Wnt signaling, and Wrch and its paralog Chp/RhoV are both implicated in oncogenic transformation and regu...

Topics

Amino Acid Sequence
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Calcium-Binding Proteins
Cell Polarity
Humans
Models, Biological
Molecular Sequence Data
Mutation
Phenotype
Receptor Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, G-Protein-Coupled

Sequence Alignment

Signal Transduction

Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 26208319
DOI: 10.1371/journal.pone.0133226
PMCID: PMC4514874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-26208319-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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