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Article

Functional ADAM12 variants modulate proteolytic activity and influence metabolic traits.

Scientific reports - 7 Jan 2026

Drobiova Hana, Al Madhoun Ashraf, Thanaraj Thangavel Alphonse, Channanath Arshad, Hebbar Prashantha, Sindhu Sardar, Ahmad Rasheed, Al-Mulla Fahd, Al-Temaimi Rabeah

Abstract excerpt

The high prevalence of insulin resistance and metabolic syndrome in Kuwait increases the risk of type 2 diabetes (T2D) and cardiovascular diseases development. Although the genetic contribution to insulin resistance and metabolic syndrome is established, the role of a disintegrin and metalloprotease 12 (ADAM12) in insulin resistance and T2D remains unclear. Our GWAS has identified four novel ADAM12 variants,...

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Topics

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Share to Diabetes Mellitus, Type 2
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Insulin Resistance

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Share to Polymorphism, Single Nucleotide

Share to Proteolysis

Source

Open in PubMed Open full text

Identifiers

PMID: 41501303
DOI: 10.1038/s41598-025-34827-1
PMCID: PMC12868893

Genes

ADAM12

Variants

rs115100580
rs41303603
rs112264074
rs140497576
rs115100580
rs41303603
rs140497576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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