Article
ADAM17_i33708A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study.
Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Dec 2010
Junyent M, Parnell L D, Lai C-Q, Arnett D K, Tsai M Y, Kabagambe E K, Straka R J, Province M, An P, Smith C E, Lee Y-C, Borecki I, Ordovás J M
Abstract excerpt
BACKGROUND AND AIMS: The disintegrin and metalloproteinase ADAM17, also known as tumor necrosis factor alpha converting enzyme, is expressed in adipocytes. Importantly, elevated levels of ADAM17 expression have been linked to obesity and insulin resistance. Therefore, the aim of this study was to evaluate the association of six ADAM17 single nucleotide polymorphisms (SNPs) (m1254A>G, i14121C>A, i33708A>G,...
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