Article

A flaw in using pre-trained pLLMs in protein-protein interaction inference models

2025-04-23

Abstract excerpt

<h4>ABSTRACT</h4> With the growing pervasiveness of pre-trained protein large language models (pLLMs), pLLM-based methods are increasingly being put forward for the protein-protein interaction (PPI) inference task. Here, we identify and confirm that existing pre-trained pLLMs are a source of data leakage for the downstream PPI task. We characterize the extent of the data leakage problem by training and comparing...

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Literature Corpus work: edabd56a-88b9-5688-9337-63a39ed6c638
DOI: 10.1101/2025.04.21.649858

Open publication

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