Article

P 3: A Framework for Predicting Protein-Protein Interactions Using Large Language Models

2025-05-22

Abstract excerpt

<title>Abstract</title> <p>The prediction of protein-protein interactions (PPIs) is essential for understanding biological functions and disease mechanisms. Traditional methods for PPI prediction often focus on physical interactions, overlooking the complex indirect relationships mediated by intermediate proteins. The recent advances in Large Language Models (LLMs) present a novel opportunity to address these cha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2ca4ef14-77af-56ed-ad1a-cca04fff06f8
DOI: 10.21203/rs.3.rs-6309474/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

P 3: A Framework for Predicting Protein-Protein Interactions Using Large Language ModelsDOI 10.21203/rs.3.rs-6309474/v1Read

Learning the language of protein-protein interactions.Semantic proximity Read

Learning the language of protein-protein interactionsSemantic proximity Read

ProtAttn-QuadNet: An attention-based deep learning framework for protein–protein interaction prediction using ProtBERT embeddingsSemantic proximity Read

ProLLM: Protein Chain-of-Thoughts Enhanced LLM for Protein-Protein Interaction PredictionSemantic proximity Read

Mechanism-Aware Protein-Protein Interaction Prediction via Contact-Guided Dual Attention on Protein Language ModelsSemantic proximity Read

Genolator: A Multimodal Large Language Model Fusing Natural Language, Genomic, and Structural Tokens for Protein Function InterpretationSemantic proximity Read

Multi-Modal Large Language Model Enables Protein Function PredictionSemantic proximity Read

Applying Protein Language Models Using Limited Dataset. Sequence-Based Hot Spot Prediction in Protein Interactions Using AutoGluonSemantic proximity Read

Sequence Representations and Their Utility for Predicting Protein-protein InteractionsSemantic proximity Read

Multi-Modal Large Language Model Enables Protein Function PredictionSemantic proximity Read

PIPENN-EMB: ensemble net and protein embeddings generalise protein interface prediction beyond homologySemantic proximity Read

Sliding Window INteraction Grammar (SWING): a generalized interaction language model for peptide and protein interactionsSemantic proximity Read