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A review on genetic alterations in CNS metastases related to breast cancer treatment. Is there a role for liquid biopsies in CSF?

Journal of neuro-oncology - 1 Mar 2023

Wessels Peter H, Boelens Mirjam C, Monkhorst Kim, Sonke Gabe S, van den Broek Daan, Brandsma Dieta

Abstract excerpt

Acquired mutations or altered gene expression patterns in brain metastases (BM) and/or leptomeningeal metastases (LM) of breast cancer may play a role in therapy-resistance and offer new molecular targets and treatment options. Despite expanding knowledge of genetic alterations in breast cancer and their metastases, clinical applications for patients with central nervous system (CNS) metastases are currently...

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PMID: 36820955
DOI: 10.1007/s11060-023-04261-2

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