Can mutation abundance assess the biological behavior of BRAFV600E-positive papillary thyroid carcinoma?

doi:10.1186/s12967-025-06493-4

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Article

Can mutation abundance assess the biological behavior of BRAFV600E-positive papillary thyroid carcinoma?

Journal of translational medicine - 1 Jul 2025

Ni Yeqin, Song Ping, Lin Xiangfeng, Shi Jingjing, Shi Qian, Li Yuanhui, Zhu Siyu, Zhou Tianhan, Xun Yanping, Zhang Shirong, Ren Xingchang, Lu Kaining, Wu Fan, Wang Wei, Zhao Pan, Zhou Rongjing, Zhang Wenhua, Li Dandan, Zhang Jiaoping, Chen Chuanghua, Mao Linlin, Zhou Li, Pan Gang, Peng You, Yu Yunxian, Chen Yuying, Ni Rong, Luo Guhan, Zhang Yu, Fang Jugao, Zheng Haitao, Luo Dingcun

Abstract excerpt

BACKGROUND: BRAFV600E mutation is the most common genetic change in papillary thyroid carcinoma (PTC). Nevertheless, the association between BRAFV600E mutation status and abundance and the biological behavior of PTC is unclear. Thus, this study investigated whether BRAFV600E mutation status and abundance are related to PTC biological behavior and whether BRAFV600E mutation abundance can be used to further...

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PMID: 40597144
DOI: 10.1186/s12967-025-06493-4
PMCID: PMC12211382

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