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Article

Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques.

Immunogenetics - 1 Jul 2015

Guo Kejun, Halemano Kalani, Schmitt Kimberly, Katuwal Miki, Wang Yaqiong, Harper Michael S, Heilman Karl J, Kuwata Takeo, Stephens Edward B, Santiago Mario L

Abstract excerpt

B cell functional defects are associated with delayed neutralizing antibody development in pathogenic lentivirus infections. However, the timeframe for alterations in the antibody repertoire and somatic hypermutation (SHM) remains unclear. Here, we utilized the SIV/rhesus macaque (RM) model to investigate the dynamics of immunoglobulin V(H) gene diversity and SHM following infection. Three RMs were infected with...

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Source

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Identifiers

PMID: 25994147
DOI: 10.1007/s00251-015-0844-3
PMCID: PMC5439441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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