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Harsh parenting and rs11621961 at the SERPINA6/1 locus: gene-environment interaction effects on hair cortisol in a Brazilian population-based longitudinal study.

Stress (Amsterdam, Netherlands) - 31 Dec 2026

Camerini Laísa, Murray Joseph, Matijasevich Alicia, Xavier Mariana Otero, Bonilla Carolina, Genro Júlia Pasqualini, Gonzalez Andrea, Rohde Luís Augusto, Goularte Laura Moreira, Santos Iná S, Oliveira Isabel O, Halligan Sarah L, Tovo-Rodrigues Luciana

Abstract excerpt

Hair cortisol concentration (HCC) reflects long-term hypothalamic-pituitary-adrenal (HPA) axis activity and is a biomarker of chronic stress. Although HCC has been linked to mental health, less is known about how genetic susceptibility and early adversity jointly influence cortisol regulation, particularly in low- and middle-income countries (LMICs). This study examined whether harsh parenting predicts adolescent...

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Brazil
Child
Gene-Environment Interaction
Hair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Longitudinal Studies

Stress, Psychological

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Identifiers

PMID: 41491671
DOI: 10.1080/10253890.2025.2611613

Genes

SERPINA6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Harsh parenting and rs11621961 at the SERPINA6/1 locus: gene-environment interaction effects on hair cortisol in a Brazilian population-based longitudinal study.PMID 41491671Read ↗

Exploring the genetic influence on hair cortisol concentration: Genetic association of rs11621961 on SERPINA6/1 locus in the 2004 Pelotas Birth Cohort (Brazil).Semantic proximity Read ↗

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Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.Semantic proximity Read ↗

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