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Exploring the genetic influence on hair cortisol concentration: Genetic association of rs11621961 on SERPINA6/1 locus in the 2004 Pelotas Birth Cohort (Brazil).

Psychoneuroendocrinology - 1 Jul 2025

Camerini Laísa, Murray Joseph, de Almeida Júlia Oliveira, Gonzalez Andrea, Santos Iná S, Barros Fernando, Oliveira Isabel O, Matijasevich Alicia, Tovo-Rodrigues Luciana

Abstract excerpt

Genetics plays a critical role in regulating cortisol, as demonstrated by the association of the SERPINA6/1 locus with plasma cortisol concentrations in a genome-wide association meta-analysis (GWAMA). These genes are integral to glucocorticoid transport and regulation, highlighting a direct genetic influence on cortisol availability. This study examines the genetic contribution to hair cortisol concentration...

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Adolescent
alpha 1-Antitrypsin
Brazil
Cohort Studies
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multifactorial Inheritance

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PMID: 40267698
DOI: 10.1016/j.psyneuen.2025.107470

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SERPINA6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Exploring the genetic influence on hair cortisol concentration: Genetic association of rs11621961 on SERPINA6/1 locus in the 2004 Pelotas Birth Cohort (Brazil).PMID 40267698Read ↗

Harsh parenting and rs11621961 at the SERPINA6/1 locus: gene-environment interaction effects on hair cortisol in a Brazilian population-based longitudinal study.Semantic proximity Read ↗

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