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KDM5 family of demethylases promotes CD44-mediated chemoresistance in pancreatic adenocarcinomas

25 Oct 2023

Abstract excerpt

A growing body of evidence suggests that the histone demethylase-lysine demethylase 5 (KDM5) family is associated with drug resistance in cancer cells. However, it is still not clear whether KDM5 family members promote chemotherapy resistance in pancreatic ductal adenocarcinomas (PDAC). Comprehensive bioinformatics analysis was performed to investigate the prognostic value, and functional mechanisms of KDM5...

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PMID: 37880235
DOI: 10.1038/s41598-023-44536-2

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