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Article

Dissecting Clonal Hematopoiesis in Tissues of Classical Hodgkin Lymphoma Patients.

Blood cancer discovery - 1 May 2021

Venanzi Alessandra, Marra Andrea, Schiavoni Gianluca, Milner Sara G, Limongello Roberto, Santi Alessia, Pettirossi Valentina, Ultimo Simona, Tasselli Luisa, Pucciarini Alessandra, Falini Lorenza, Sciabolacci Sofia, Martelli Maria Paola, Sportoletti Paolo, Ascani Stefano, Falini Brunangelo, Tiacci Enrico

Abstract excerpt

Clonal hematopoiesis predisposes to hematological malignancies. However, clonal hematopoiesis is understudied in classical Hodgkin lymphoma (cHL), a mature B-cell neoplasm exhibiting the most abundant microenvironment. We analyzed clonal hematopoiesis in 40 cHL cases by sequencing microdissected tumor cells and matched normal cells from blood and/or lymph nodes. Five patients had blood and/or tissue clonal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34164626
DOI: 10.1158/2643-3230.BCD-20-0203
PMCID: PMC7611041

Genes

DNMT3A
NPM1
TET2

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