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Article

The landscape and evolution of clonal hematopoiesis in chronic lymphocytic leukemia.

Blood - 19 Mar 2026

Al-Sawaf Othman, Locher Benjamin N, Christen Friederike, Hablesreiter Raphael, Rajamani Anantharamanan, Robrecht Sandra, Zhang Can, Fink Anna Maria, Tausch Eugen, Schneider Christof, Ritgen Matthias, Kreuzer Karl-Anton, Kopp Klara, Mertz Marie-Elisa, Fustero-Torre Coral, Kleo Karsten, Seymour John, Blombery Piers, Bullinger Lars, Chyla Brenda, Jin Hyun Yong, Jiang Yanwen, Stilgenbauer Stephan, Hallek Michael, Eichhorst Barbara, Langerbeins Petra, Fischer Kirsten, Damm Frederik

Abstract excerpt

ABSTRACT: Chronic lymphocytic leukemia (CLL) and clonal hematopoiesis (CH) both commonly occur in older individuals. To characterize CH in CLL, 620 patients were analyzed (CLL12 [ibrutinib vs placebo] and CLL14 [venetoclax-obinutuzumab (Ven-Obi) vs chlorambucil-obinutuzumab (Clb-Obi)]) using error-corrected next-generation sequencing with a variant allele frequency (VAF) threshold of 0.5%. Median follow-up was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41528026
DOI: 10.1182/blood.2025029905
PMCID: PMC13014086

Genes

BAX
ASXL1
CD34
DNMT3A
PPM1D
TET2
TP53
U2AF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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