Article
Co-aggregation of annexin A11 and TDP-43 in FTLD/MND with primary lateral sclerosis phenotype.
Acta neuropathologica communications - 4 Jan 2026
Tarutani Airi, Nonaka Takashi, Ohtani Reiko, Imai Kazunori, Ito Yasuhiro, Tsuji Hiroshi, Mochizuki Akihide, Tamaoka Akira, Arai Tetsuaki, Robinson Andrew C, Mann David M A, Kosaka Takayuki, Takahashi Hitoshi, Kakita Akiyoshi, Yoshida Mari, Hasegawa Masato
Abstract excerpt
TDP-43 proteinopathies, such as frontotemporal degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), are classified into five neuropathological subtypes, Types A to E, according to the morphology of TDP-43 inclusions. Recent cryo-electron microscopy analysis of FTLD-TDP cases demonstrated that TDP-43 filaments composing the inclusions are structurally different depending on the subtype, and remarkably,...
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