Article
Levodopa-induced dyskinesia in early-onset Parkinson's disease (EOPD) associates with glucocerebrosidase mutation: A next-generation sequencing study in EOPD patients in Thailand.
PloS one - 1 Jan 2023
Thanprasertsuk Sekh, Phowthongkum Prasit, Hopetrungraung Thitipong, Poorirerngpoom Chalalai, Sathirapatya Tikumphorn, Wichit Patsorn, Phokaewvarangkul Onanong, Vongpaisarnsin Kornkiat, Bongsebandhu-Phubhakdi Saknan, Bhidayasiri Roongroj
Abstract excerpt
BACKGROUND: With the benefit of using next-generation sequencing (NGS), our aim was to examine the prevalence of known monogenic causes in early-onset Parkinson's disease (EOPD) patients in Thailand. The association between clinical features, such as levodopa-induced dyskinesia (LID), and genotypes were also explored. METHOD: NGS studies were carried out for EOPD patients in the Tertiary-referral center for...
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