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Article

Endothelial Cell Phenotypic Plasticity in Cardiovascular Physiology and Disease: Mechanisms and Therapeutic Prospects.

American journal of hypertension - 16 Jun 2025

de Queiroz Diego B, Parente Juliana M, Pernomian Laena, Waigi Emily W, Alfaidi Mabruka, Tan Wenbin, McCarthy Cameron G, Wenceslau Camilla F

Abstract excerpt

Endothelial cells (ECs) are a highly specialized and heterogeneous population that plays a fundamental role in maintaining vascular homeostasis, immune regulation, and blood flow control. Beyond serving as a physical barrier, ECs exhibit remarkable plasticity, undergoing phenotypic transitions, including endothelial-to-mesenchymal (EndMT), endothelial-to-hematopoietic (EndHT), endothelial-to-osteoblast (EndOT)...

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Identifiers

PMID: 39989120
DOI: 10.1093/ajh/hpaf027
PMCID: PMC12187589

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