Article
Vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D levels: association with cerebrovascular disease in sickle cell anemia.
Pediatric hematology and oncology - 1 Mar 2026
Arcanjo Gabriela S, Batista Jéssica V G F, Oliveira Jéssica M F, Domingos Igor F, Batista Thais H C, Pereira-Martins Diego A, Hatzlhofer Betânia L D, Araújo Amanda B S, França Talita S S, Anjos Ana C M, Araujo Aderson S, Costa Fernando F, Lucena-Araujo Antonio R, Bezerra Marcos A C
Abstract excerpt
Sickle cell anemia (SCA) is associated with a high prevalence of cerebrovascular complications, such as ischemic stroke, particularly at young ages. Among various molecules, vitamin D has been implicated in stroke occurrence. By binding to the vitamin D receptor (VDR), vitamin D regulates several mechanisms, potentially influencing pathways involved in the pathophysiology of cerebral vasculopathy. Here, we...
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