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Article

Chemogenetic control of GABAergic neurons within the interpeduncular nucleus reveals dissociable behavioral components of the nicotine withdrawal phenotype.

Neurobiology of disease - 1 Jan 2026

Miguelez Fernández Anabel M M, Netherton Shana, Niladhuri Seshadri B, Brown Alexander C, Rivera Patricia, Tseng Kuei Y, Peters Christian J

Abstract excerpt

Chronic exposure to nicotine results in the development of a dependent state such that a withdrawal syndrome is elicited upon cessation of nicotine. The interpeduncular nucleus (IPN) contains a high concentration of nicotinic acetylcholine receptors (nAChRs) and has been identified as a key brain region involved in nicotine withdrawal. Here we investigated the contribution of two distinct subpopulations of IPN...

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Identifiers

PMID: 41443382
DOI: 10.1016/j.nbd.2025.107240
PMCID: PMC13348565

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