Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA binding protein with multiple splicing (RBPMS) promotes contractile phenotype splicing in human embryonic stem cell-derived vascular smooth muscle cells.

Cardiovascular research - 14 Dec 2024

Jacob Aishwarya G, Moutsopoulos Ilias, Petchey Alex, Kollyfas Rafael, Knight-Schrijver Vincent R, Mohorianu Irina, Sinha Sanjay, Smith Christopher W J

Abstract excerpt

AIMS: Differentiated vascular smooth muscle cells (VSMCs) express a unique network of mRNA isoforms via smooth muscle-specific alternative pre-mRNA splicing (SM-AS) in functionally critical genes, including those comprising the contractile machinery. We previously described RNA Binding Protein with Multiple Splicing (RBPMS) as a potent driver of differentiated SM-AS in the rat PAC1 VSMC cell line. What is unknown...

Topics

Join the communities discussing this publication.

Alternative Splicing
Human Embryonic Stem Cells
Muscle, Smooth, Vascular
Myocytes, Smooth Muscle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repressor Proteins

RNA-Binding Proteins

RNA Splicing Factors

Vasoconstriction

Source

Open in PubMed Open full text

Identifiers

PMID: 39248180
DOI: 10.1093/cvr/cvae198
PMCID: PMC11646123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA binding protein with multiple splicing (RBPMS) promotes contractile phenotype splicing in human embryonic stem cell-derived vascular smooth muscle cells.PMID 39248180Read ↗

RBPMS promotes contractile smooth muscle splicing and alters phenotypic behaviour of human embryonic stem cell derived vascular smooth muscle cellsSemantic proximity Read ↗

The Expanding Role of Alternative Splicing in Vascular Smooth Muscle Cell Plasticity.Semantic proximity Read ↗

RBPMS and RBPMS2 Cooperate to Safeguard Cardiac SplicingSemantic proximity Read ↗

Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4).Semantic proximity Read ↗

Genomic, transcriptomic and proteomic depiction of iPSC-derived smooth muscle cells as emerging cellular models for arterial diseasesSemantic proximity Read ↗

LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin.Semantic proximity Read ↗

Long non‐coding RNAs influence the transcriptome in pulmonary arterial hypertension: the role of PAXIP1‐AS1Semantic proximity Read ↗

RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac FunctionSemantic proximity Read ↗

circFAM53B-1 and circFAM53B-2 drive VSMC phenotypic modulation via ISG15-mediated suppression of SRF.Semantic proximity Read ↗

LncRNA RP11-301G19.1 is required for the maintenance of vascular smooth muscle cell contractile phenotype via sponging miR-17-5P/ATOH8 axis.Semantic proximity Read ↗

RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicingSemantic proximity Read ↗

circ‑Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.