Article
Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2019
Yim John H, Choi Audrey H, Li Arthur X, Qin Hanjun, Chang Sue, Tong Sun-Wing T, Chu Peiguo, Kim Byung-Wook, Schmolze Daniel, Lew Ryan, Ibrahim Yasmine, Poroyko Valeriy A, Salvatierra Sylvana, Baker Alysha, Wang Jinhui, Wu Xiwei, Pfeifer Gerd P, Fong Yuman, Hahn Maria A
Abstract excerpt
PURPOSE: Thyroid cancer is frequently difficult to diagnose due to an overlap of cytologic features between malignant and benign nodules. This overlap leads to unnecessary removal of the thyroid in patients without cancer. While providing some improvement over cytopathologic diagnostics, molecular methods frequently fail to provide a correct diagnosis for thyroid nodules. These approaches are based on the...
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