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Article

Suppressing the OTUD7A/KDM5B/GABPA axis enhances the sensitivity of cisplatin through inducing ferroptosis in KRAS-mutant LUAD.

Cell death & disease - 20 Dec 2025

Si Rujia, Shen Ziyang, Sui Ying, Shi Yue, Zhang Yihan, Hu Bowen, Chen Xin, Feng Bing, Zhu Miao Lin, Sha Xiaofeng, Ding Ning, Zhou Guoren, Jiang Feng, Xu Cong, Shen Bo

Abstract excerpt

KRAS-mutant lung adenocarcinoma (LUAD), due to its evolution of more complex antioxidant metabolic mechanisms, exhibits poorer sensitivity to conventional platinum-based drugs compared to other types of LUAD. Ferroptosis, as a means of inducing cell death in cancer therapy, shows unique features and potential therapeutic effects compared to the conventional form of apoptosis, which is frequently obstructed by...

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Identifiers

PMID: 41422226
DOI: 10.1038/s41419-025-08337-x
PMCID: PMC12848020

Genes

KRAS
GABPA
KDM5B
OTUD7A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Suppressing the OTUD7A/KDM5B/GABPA axis enhances the sensitivity of cisplatin through inducing ferroptosis in KRAS-mutant LUAD.PMID 41422226Read ↗

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