Article

Why SARS-CoV-2 Omicron variant is milder? A single high-frequency mutation of structural envelope protein matters

2022-02-02

Abstract excerpt

SARS-CoV-2 Omicron variant is highly transmissible and extensive morbidity, which has raised concerns for antiviral therapy. In addition, the molecular basis for the attenuated pathogenicity and replication capacity of Omicron remains elusive. Here, we report for the first time that a high-frequency mutation T9I on 2-E of SARS-CoV-2 variant Omicron forms a non-selective ion channel with abolished calcium permeabil...

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Literature Corpus work: bc077ba9-ef8c-5730-bb72-c6f930448dd1
DOI: 10.1101/2022.02.01.478647

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