Structural resilience of conserved-site mutations in the MERS-CoV membrane protein: insights into stability and conformational dynamics.

Abstract excerpt

MERS-CoV remains a significant global health challenge due to sporadic outbreaks. The ongoing emergence of new viral variants, particularly among betacoronaviruses, underscores the importance of understanding mutations in structural proteins. The membrane (M) protein, a highly conserved structural component essential for viral assembly, is a promising target for therapeutic intervention, and any mutations in this...

Topics

• Molecular Dynamics Simulation
• Middle East Respiratory Syndrome Coronavirus
• Mutation
• Protein Stability
• Viral Matrix Proteins