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The SARS-CoV-2 envelope (E) protein has evolved towards membrane topology robustness

24 Mar 2021

Abstract excerpt

Single-spanning SARS-CoV-2 envelope (E) protein topology is a major determinant of protein quaternary structure and function. Charged residues distribution in E protein sequences from highly pathogenic human coronaviruses (i.e., SARS-CoV, MERS-CoV and SARS-CoV-2) stabilize Ntout-Ctin membrane topology. E protein sequence could have evolved to ensure a more robust membrane topology from MERS-CoV to SARS-CoV and...

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PMID: 33771486
DOI: 10.1016/j.bbamem.2021.183608

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