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Article

Molecular architecture and functional analysis of NetB, a pore-forming toxin from Clostridium perfringens.

The Journal of biological chemistry - 1 Feb 2013

Savva Christos G, Fernandes da Costa Sérgio P, Bokori-Brown Monika, Naylor Claire E, Cole Ambrose R, Moss David S, Titball Richard W, Basak Ajit K

Abstract excerpt

NetB is a pore-forming toxin produced by Clostridium perfringens and has been reported to play a major role in the pathogenesis of avian necrotic enteritis, a disease that has emerged due to the removal of antibiotics in animal feedstuffs. Here we present the crystal structure of the pore form of NetB solved to 3.9 Å. The heptameric assembly shares structural homology to the staphylococcal α-hemolysin. However,...

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Identifiers

PMID: 23239883
DOI: 10.1074/jbc.M112.430223
PMCID: PMC3561570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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