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Genome-wide association study identifies novel variants in olfactory, vitamin A, vitamin B, and cadherin pathways associated with learning and memory.

Scientific reports - 18 Dec 2025

Hopkins Lloyd N, Avgan Nesli, Sutherland Heidi G, Fernandez Francesca E, Knowles Emma E M, Haupt Larisa M, Blangero John, Glahn David C, Shum David H K, Lea Rod A, Griffiths Lyn R

Abstract excerpt

Learning and memory, as fundamental components of human cognition, are heritable traits that are highly variable between individuals and within populations. Investigation into the genetic basis of cognition is a prominent area of research, with genetic associations being previously reported for a wide range of cognitive phenotypes. Here we utilise a genome-wide association study (GWAS) approach to evaluate the...

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Identifiers

PMID: 41413636
DOI: 10.1038/s41598-025-32828-8
PMCID: PMC12830837

Genes

PC
GNG12
NXPE3
PPARD
RBFOX1
RD3
SLC19A3
WLS

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