Characterization of the Immunogenomic Landscape of Ovarian Cancer Uncovers a Distinct Subset of Endometroid Tumors Associated with High CST2 Expression and a Favorable Prognosis.

doi:10.1158/2767-9764.CRC-25-0150

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Characterization of the Immunogenomic Landscape of Ovarian Cancer Uncovers a Distinct Subset of Endometroid Tumors Associated with High CST2 Expression and a Favorable Prognosis.

Cancer research communications - 1 Jan 2026

Boyle James, Zaucha Jan, Ng Felicia, Spitzmüller Andreas, Vuko Miljenka, Segerer Felix J, Azqueta-Gavaldon Monica, Testori Marco, Raymond Amelia, Nuttall Barrett R B, Storti Andrea Ennio, Gulati Sakshi, Gill Shaan, Surace Michael, Marco-Casanova Paola, Jones Emma V, Sidders Ben S, Reis-Filho Jorge S, Scaltriti Maurizio, Semertzidou Anita, Angell Helen K

Abstract excerpt

Ovarian cancers with similar histopathologic but diverse immunogenomic profiles may require different treatment regimens to achieve the best clinical outcomes. The development of optimal treatment regimens will thus require an understanding of the main ways in which ovarian cancers differ with respect to their immunogenomic profiles. We used a multimodal latent variable model to enable an integrated analysis of...

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PMID: 41411187
DOI: 10.1158/2767-9764.CRC-25-0150
PMCID: PMC12848861

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CST2

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