Article
Higher Promoter Methylation of the Ubiquitin-Associated and SH3 Domain Containing A (UBASH3A) Gene Is Associated With T-Lymphocyte Ontogeny and Reduced Susceptibility to Early-Onset Sepsis.
The Journal of infectious diseases - 17 Mar 2026
Wang Ziyi, Amenyogbe Nelly, Ben-Othman Rym, Cai Bing, Lo Mandy, Idoko Olubukola T, Odumade Oludare A, Falsafi Reza, Blimkie Travis M, An Andy, Shannon Casey P, Montante Sebastiano, Dhillon Bhavjinder K, Diray-Arce Joann, Ozonoff Al, Smolen Kinga K, Brinkman Ryan R, McEnaney Kerry, Angelidou Asimenia, Richmond Peter, Tebbutt Scott J, Kampmann Beate, Hancock Robert E W, Lee Amy H Y, Levy Ofer, Kollmann Tobias R, Martino David
Abstract excerpt
We investigated the genetic and epigenetic regulation of the UBASH3A gene and its association with early-onset sepsis. Using matched whole blood DNA methylation, gene expression, genotypes, and immune cell counts from the EPIC-HIPC newborn cohort, we report that promoter methylation was negatively correlated (Pearson r = -0.5, P < 2.2 × 10-16) with ontogenetic changes in UBASH3A gene expression and circulating...
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